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An anonymous reader quotes a report from IEEE Spectrum: In a development straight out of science fiction, Australian startup Cortical Labs has released what it calls the world's first code-deployable biological computer. The CL1, which debuted in March, fuses human brain cells on a silicon chip to process information via sub-millisecond electrical feedback loops. Designed as a tool for neuroscience and biotech research, the CL1 offers a new way to study how brain cells process and react to stimuli. Unlike conventional silicon-based systems, the hybrid platform uses live human neurons capable of adapting, learning, and responding to external inputs in real time. "On one view, [the CL1] could be regarded as the first commercially available biomimetic computer, the ultimate in neuromorphic computing that uses real neurons," says theoretical neuroscientist Karl Friston of University College London. "However, the real gift of this technology is not to computer science. Rather, it's an enabling technology that allows scientists to perform experiments on a little synthetic brain."
The first 115 units will begin shipping this summer at $35,000 each, or $20,000 when purchased in 30-unit server racks. Cortical Labs also offers a cloud-based "wetware-as-a-service" at $300 weekly per unit, unlocking remote access to its in-house cell cultures. Each CL1 contains 800,000 lab-grown human neurons, reprogrammed from the skin or blood samples of real adult donors. The cells remain viable for up to six months, fed by a life-support system that supplies nutrients, controls temperature, filters waste, and maintains fluid balance. Meanwhile, the neurons are firing and interpreting signals, adapting from each interaction.
The CL1's compact energy and hardware footprint could make it attractive for extended experiments. A rack of CL1 units consumes 850-1,000 watts, notably lower than the tens of kilowatts required by a data center setup running AI workloads. "Brain cells generate small electrical pulses to communicate to a broader network," says Cortical Labs Chief Scientific Officer Brett Kagan. "We can do something similar by inputting small electrical pulses representing bits of information, and then reading their responses. The CL1 does this in real time using simple code abstracted through multiple interacting layers of firmware and hardware. Sub-millisecond loops read information, act on it, and write new information into the cell culture." The company sees CL1 as foundational for testing neuropsychiatric treatments, leveraging living cells to explore genetic and functional differences. "It allows people to study the effects of stimulation, drugs and synthetic lesions on how neuronal circuits learn and respond in a closed-loop setup, when the neuronal network is in reciprocal exchange with some simulated world," says theoretical neuroscientist Karl Friston of University College London. "In short, experimentalists now have at hand a little 'brain in a vat,' something philosophers have been dreaming about for decades."
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Ars Technica's Benj Edwards reports: In 1979, Atari released the Atari 400 and 800, groundbreaking home computers that included custom graphics and sound chips, four joystick ports, and the ability to run the most advanced home video games of their era. These machines, which retailed for $549 and $999, respectively, represented a leap in consumer-friendly personal computing, with their modular design and serial I/O bus that presaged USB. Now, 46 years later, a hobbyist has shrunk down the system hardware to a size that would have seemed like science fiction in the 1970s.
Polish engineer Piotr "Osa" Ostapowicz recently unveiled "Atarino," which may be the world's smallest 8-bit Atari computer re-creation, according to retro computing site Atariteca. The entire system -- processor, graphics chips, sound hardware, and memory controllers -- fits on a module measuring just 2x1.5 centimeters (about 0.79x0.59 inches), which is roughly the size of a postage stamp.
Ostapowicz's creation reimplements the classic Atari XL/XE architecture using modern FPGA (field-programmable gate array) technology. Unlike software emulators that simulate old hardware (and modern recreations that run them, like the Atari 400 Mini console) on a complete computer system of another architecture, Atarino reproduces the original Atari components faithfully at the logic level, allowing it to run vintage software while maintaining compatibility with original peripherals. [...] The project, which began over a decade ago and was first publicly demonstrated in December 2023, includes a 6502C processor, ANTIC and GTIA graphics chips, POKEY sound chip, and memory controllers onto a single Lattice UP5K FPGA chip. Despite its tiny size, the system can run at clock speeds up to 31 MHz -- far faster than the original hardware's 1.79 MHz. While the Atarino can run vintage software and work with the original peripherals, it brings several key improvements -- including a modernized 6502 core with added instructions, a more efficient memory architecture, enhanced video output via VGA and HDMI, extended graphics modes, refined sound chip emulation, modular hardware design, support for modern connectivity like Wi-Fi and Ethernet, and compatibility with contemporary development tools like CC65 and Visual Studio Code.
Ostapowicz "plans to release complete kits with documentation, inviting the retrocomputing community to experiment with the hardware," adds Edwards.
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